My assumption is that if Google (which deploys the Yubikey Nano across their employees) is willing to make the leap that there'd be no way to trigger the button

My assumption is that if Google (which deploys the Yubikey Nano across their employees) is willing to make the leap that there'd be no way to trigger the button press via USB, then assuming Tomu has done their due diligence, it's impossible to do so on here.