2 ms·

The effects of Myc have been tested in many different ways since that study. Just type Myc and transcription into pubmed and you can see for yourself. I'm not

by Gatsky 8y ago

The effects of Myc have been tested in many different ways since that study. Just type Myc and transcription into pubmed and you can see for yourself. I'm not sure what you are trying to achieve by making outlandish comments about cutting funding or jobs programs (the idea that cancer research is a jobs program is utterly hilarious!!), but it doesn't really seem you read my comment.

nonbel 8y ago
I don't see whats confused you about my post. If no one cares whether the authors got it all wrong and "Transcriptional amplification in tumor cells with elevated c-Myc under conditions xyz" should actually be "Transcriptional amplification in tumor cells with depressed c-Myc under conditions xyz", then why was this funded? If someone does care then it should be replicated.
- Gatsky 8y ago
  > If someone does care then it should be replicated. It is tested in other forms, but isn't generally replicated in the sense you seem to think is paramount. Nor should it be. I'll give you a silly example - would you support a project to go back and replicate electromagnetism experiments performed at the start of the century? Say we do repeat Millikan's oil drop experiment and get a different result (which is actually what happened) - does this mean there is a reproducibility crisis in physics? If we don't repeat the exact experiment, does that mean that Millikan shouldn't have received funding? Why is it that replicating the result the way Millikan did it more useful than doing other related experiments with more sophisticated or different apparatus? The latter is actually MORE useful.
  - nonbel 8y ago
    >"would you support a project to go back and replicate electromagnetism experiments performed at the start of the century?" Yes, of course! That is a great idea. Everyone should be doing this experiment in high school or undergrad science class by now. In fact that seems to be a thing: https://hepweb.ucsd.edu/2dl/pasco/Millikans%20Oil%20Drop%20Manual%20(AP-8210).pdf https://hepweb.ucsd.edu/2dl/pasco/Millikans%20Oil%20Drop%20M... https://www.ucd.ie/t4cms/EXP18%20millikan.pdf https://www.ucd.ie/t4cms/EXP18%20millikan.pdf
nonbel 8y ago
Maybe this makes more sense to you: If no one cares whether the authors got it all wrong and "Transcriptional amplification in tumor cells with elevated c-Myc under conditions xyz" should actually be "Transcriptional suppression in tumor cells with elevated c-Myc under conditions xyz", then why was this funded?

by Gatsky 8y ago

nonbel 8y ago

I don't see whats confused you about my post. If no one cares whether the authors got it all wrong and "Transcriptional amplification in tumor cells with elevated c-Myc under conditions xyz" should actually be "Transcriptional amplification in tumor cells with depressed c-Myc under conditions xyz", then why was this funded? If someone does care then it should be replicated.

Gatsky 8y ago
> If someone does care then it should be replicated. It is tested in other forms, but isn't generally replicated in the sense you seem to think is paramount. Nor should it be. I'll give you a silly example - would you support a project to go back and replicate electromagnetism experiments performed at the start of the century? Say we do repeat Millikan's oil drop experiment and get a different result (which is actually what happened) - does this mean there is a reproducibility crisis in physics? If we don't repeat the exact experiment, does that mean that Millikan shouldn't have received funding? Why is it that replicating the result the way Millikan did it more useful than doing other related experiments with more sophisticated or different apparatus? The latter is actually MORE useful.
- nonbel 8y ago
  >"would you support a project to go back and replicate electromagnetism experiments performed at the start of the century?" Yes, of course! That is a great idea. Everyone should be doing this experiment in high school or undergrad science class by now. In fact that seems to be a thing: https://hepweb.ucsd.edu/2dl/pasco/Millikans%20Oil%20Drop%20Manual%20(AP-8210).pdf https://hepweb.ucsd.edu/2dl/pasco/Millikans%20Oil%20Drop%20M... https://www.ucd.ie/t4cms/EXP18%20millikan.pdf https://www.ucd.ie/t4cms/EXP18%20millikan.pdf

nonbel 8y ago

Maybe this makes more sense to you: If no one cares whether the authors got it all wrong and "Transcriptional amplification in tumor cells with elevated c-Myc under conditions xyz" should actually be "Transcriptional suppression in tumor cells with elevated c-Myc under conditions xyz", then why was this funded?