From what I understand, artificial ECMs can be more difficult to build in some ways, but if you can figure out how to incorporate the right signaling factors in

From what I understand, artificial ECMs can be more difficult to build in some ways, but if you can figure out how to incorporate the right signaling factors into an artificial collagen matrix, you can avoid a lot of challenging biocompatibility/immune reaponse problems. Also, I believe most cells are differentiated before being seeded onto the scaffold.