6 ms·
I wonder how much this process reverses the age of the lungs, if you take the lungs of an 80 year old, wash them, reseed them and put them in a 20 year old, wha
by Brakenshire 8y ago
I wonder how much this process reverses the age of the lungs, if you take the lungs of an 80 year old, wash them, reseed them and put them in a 20 year old, what’s the result?
- biofox 8y agoI don't work in this area, but ECM scaffolds undergo significant change with age. Crosslinks and age-related remodelling degrade the mechanical properties of the scaffold and interfere with normal cell migration and differentiation. You would want to start with a healthy organ before decellularising and reseeding.
- improbable22 8y agoBut perhaps not quite as critical as for current transplants? At least that's my uneducated guess... anyone know?
- thefounder 8y agoIf that would work I guess people would like to "refresh" their organs anyway from time to time to avoid failure.
- dmurray 8y agoYes, though I would expect the risk of complications from this procedure will outweigh the benefit for healthy patients for many years after it becomes a "routine" operation for those with lung disease.
- kls 8y agoWeird thought what if a 20'something put cells in a bank and had organs generated from them later in life.