For once jam Wireless/GSM. This will prevent remote controlling and will require some sort of self-guidance system (neural net, pre-programmed route). You can

For once jam Wireless/GSM. This will prevent remote controlling and will require some sort of self-guidance system (neural net, pre-programmed route). You can also take any drone down. There are various solutions, from hawks (as in bird) to wire-net launchers and lasers.