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Gene editing crunches an organism’s genome into single, giant DNA molecule
- kurthr 8y agoA good discussion by one of the scientists on why it was challenging to create "mega-chromasomes". It's interesting, because both groups attempting it were unable to delete one of the centromeres (#15) for unknown reasons. https://bioengineeringcommunity.nature.com/users/170546-jingchuan-luo/posts/37262-engineering-yeast-megachromosomes https://bioengineeringcommunity.nature.com/users/170546-jing... Also see the original Nature paper: https://go.nature.com/2n43y6c https://go.nature.com/2n43y6c