3 ms·
If I remember correctly, the mechanism underlying the glutamate toxicity is mutant SOD, which is made as a response to oxidative stress. The glutamate is simply
by jf- 8y ago
If I remember correctly, the mechanism underlying the glutamate toxicity is mutant SOD, which is made as a response to oxidative stress. The glutamate is simply an excitory stimulus that makes free radicals which need to be mopped up by something. Could be that other proteinopathies are a similar reaction to oxidative stress, and something that promotes GABA, such as alcohol, has a beneficial effect. But of course I’m only speculating.
- Herodotus38 8y agoI'm not knowledgeable enough about the biology to really add much to what you said there either, even though I deal with the end results. Systems biology is one of those areas where I think AI will make a huge difference in the future. If you are interested in some thoughts on this listen to the first hour and a half talk by Craig Mundie (you can skip first 20 minutes of intro by Collins) of this recent NIH videocast on AI in medicine: https://videocast.nih.gov/summary.asp?live=28053&bhcp=1 https://videocast.nih.gov/summary.asp?live=28053&bhcp=1