Not in-flight as far as we know, but a Boeing 757 was hacked in a proof of concept attack on the tarmac quite recently https://www.computing.co.uk/ctg/news/302

Not in-flight as far as we know, but a Boeing 757 was hacked in a proof of concept attack on the tarmac quite recently https://www.computing.co.uk/ctg/news/3020901/dhs-team-manages-to-hack-boeing-757 https://www.computing.co.uk/ctg/news/3020901/dhs-team-manage...