> I also saw nothing anywhere about how if you modify your config file and down/up with wg-quick it'll delete anything you entered in your config as the 'down'

> I also saw nothing anywhere about how if you modify your config file and down/up with wg-quick it'll delete anything you entered in your config as the 'down' will write back the current state of the interface. No. Only if you've explicitly chosen to add "SaveConfig = true" to the config file, which by default is not there.