4 ms·
Is there some route to naloxone that I am not aware of that doesn't start from some opiate or opium alkaloid? The morphine total syntheses I've read were rather
by vzcx 8y ago
Is there some route to naloxone that I am not aware of that doesn't start from some opiate or opium alkaloid? The morphine total syntheses I've read were rather involved and low-yield. Perhaps progress made on the biosynthetic step through reticuline? That would be exciting.
- refurb 8y agoArticle covers that. They start with oxycodone. From that a reduction to hydromorphone and then methylation to nalaxone. Not easy chemistry, but only two steps.