5 ms·

Full Genomes Corporation[1] will do WGS at 30x for $1295, WGS at 20x for $900, and Long Read WGS (newer technology) for $2900. For Prime Day, Dante Labs[2] had

Full Genomes Corporation[1] will do WGS at 30x for $1295, WGS at 20x for $900, and Long Read WGS (newer technology) for $2900. For Prime Day, Dante Labs[2] had a sale on a 30x WGS for $349; it's still on sale for $499. Once you have a WGS you might consider donating it to the Harvard Personal Genomes Project[3], Open Humans[4], or putting it on GitHub[5]. [1]: https://www.fullgenomes.com/whole-genome-sequencing/ https://www.fullgenomes.com/whole-genome-sequencing/ [2]: https://us.dantelabs.com/products/whole-genome-sequencing-wgs-full-dna-analysis https://us.dantelabs.com/products/whole-genome-sequencing-wg... [3]: https://pgp.med.harvard.edu/ https://pgp.med.harvard.edu/ [4]: https://www.openhumans.org/ https://www.openhumans.org/ [5]: https://github.com/beaugunderson/genome https://github.com/beaugunderson/genome

fapjacks 8y ago
I've purchased a handful of Dante Labs 30x WGS kits on Amazon over the last couple of days. You didn't hear it from me, but the kits are still on sale on Amazon for $349... ... And an additional secret $100 discount during checkout. This is $250 WGS at 30x coverage. It should be front-page news.
- tbrock 8y ago
  Can you provide a link or more info? I’m not seeing it. It seems to be at $499.
  - fapjacks 8y ago
    It looks like this listing ended about the same time that I posted about it, or at least in the time between my posting about it and six hours ago. Now there are only $499 kits by third-party sellers. But when there was still FBA inventory (fulfilled by Amazon), it was $349 plus the secret $100 "promotion" discount during checkout.
- cncrnd 8y ago
  Are the results of WGS + analysis with promethease more insightful than the results of 23andMe?
  - berberous 8y ago
    Not for me. You obviously have more data, but like 23andme,I found very little of it to be actionable or useful. YMMV
    - cncrnd 8y ago
      What'd you use to analyze your genome, promethease? I think that increased risks of x,y,z would be good to be aware of.
      - berberous 8y ago
        Yes, promethease. Have you done 23andme? It also gives you increased risks, but usually none that are helpful. For example, if it says that you have some Snaps that increase your risks of prostate cancer from 1 in 100 to 2in 100, what do you do with that? 2 in 100 is still so low (even though double baseline population risk), that it's not going to effect my decisions. That's also assuming it's accurate -- other SNPs may lower your risk.
        cncrnd 8y ago
        I haven't done it because of privacy concerns, but I am considering WGS through a lab then promethease instead. I don't think understanding risk would affect my decisions much either, but I'd probably get familiar with the symptoms of things I have a higher chance of to be able to recognize issues earlier. If there are screenings available, maybe I'd start doing them a little earlier or more frequently than prescribed.
  - aaavl2821 8y ago
    23andme measures presence / absence of ~1M specific single-nucleotide polymorphism mutations (a SNP is a change in one "letter" of DNA), out of 10M+ total mutations known SNP mutations. Whole genome sequencing reads basically your entire genome, which consists of approximately 3 billion base pairs so 23andme is like a unit test, and WGS is like the source code for the whole system that said, we don't really know how to interpret most of the source code, so for a lot of cases (esp those that don't relate to medical treatment or research), 23andme is probably fine
- mfkp 8y ago
  Link? I'm seeing $499 in checkout on Amazon.
  - fapjacks 8y ago
    It looks like this listing ended about the same time that I posted about it, or at least in the time between my posting about it and six hours ago. Now there are only $499 kits by third-party sellers. But when there was still FBA inventory (fulfilled by Amazon), it was $349 plus the secret $100 "promotion" discount during checkout.
berberous 8y ago
Why is Dante much cheaper than Full Genomes? What's the benefit of "Long Read WGS"?
aaavl2821 8y ago
What's in it for these companies? Seems like there must be a catch

fapjacks 8y ago

I've purchased a handful of Dante Labs 30x WGS kits on Amazon over the last couple of days. You didn't hear it from me, but the kits are still on sale on Amazon for $349... ... And an additional secret $100 discount during checkout. This is $250 WGS at 30x coverage. It should be front-page news.

tbrock 8y ago
Can you provide a link or more info? I’m not seeing it. It seems to be at $499.
- fapjacks 8y ago
  It looks like this listing ended about the same time that I posted about it, or at least in the time between my posting about it and six hours ago. Now there are only $499 kits by third-party sellers. But when there was still FBA inventory (fulfilled by Amazon), it was $349 plus the secret $100 "promotion" discount during checkout.
cncrnd 8y ago
Are the results of WGS + analysis with promethease more insightful than the results of 23andMe?
- berberous 8y ago
  Not for me. You obviously have more data, but like 23andme,I found very little of it to be actionable or useful. YMMV
  - cncrnd 8y ago
    What'd you use to analyze your genome, promethease? I think that increased risks of x,y,z would be good to be aware of.
    - berberous 8y ago
      Yes, promethease. Have you done 23andme? It also gives you increased risks, but usually none that are helpful. For example, if it says that you have some Snaps that increase your risks of prostate cancer from 1 in 100 to 2in 100, what do you do with that? 2 in 100 is still so low (even though double baseline population risk), that it's not going to effect my decisions. That's also assuming it's accurate -- other SNPs may lower your risk.
      - cncrnd 8y ago
        I haven't done it because of privacy concerns, but I am considering WGS through a lab then promethease instead. I don't think understanding risk would affect my decisions much either, but I'd probably get familiar with the symptoms of things I have a higher chance of to be able to recognize issues earlier. If there are screenings available, maybe I'd start doing them a little earlier or more frequently than prescribed.
- aaavl2821 8y ago
  23andme measures presence / absence of ~1M specific single-nucleotide polymorphism mutations (a SNP is a change in one "letter" of DNA), out of 10M+ total mutations known SNP mutations. Whole genome sequencing reads basically your entire genome, which consists of approximately 3 billion base pairs so 23andme is like a unit test, and WGS is like the source code for the whole system that said, we don't really know how to interpret most of the source code, so for a lot of cases (esp those that don't relate to medical treatment or research), 23andme is probably fine
mfkp 8y ago
Link? I'm seeing $499 in checkout on Amazon.
- fapjacks 8y ago
  It looks like this listing ended about the same time that I posted about it, or at least in the time between my posting about it and six hours ago. Now there are only $499 kits by third-party sellers. But when there was still FBA inventory (fulfilled by Amazon), it was $349 plus the secret $100 "promotion" discount during checkout.

berberous 8y ago

Why is Dante much cheaper than Full Genomes? What's the benefit of "Long Read WGS"?

aaavl2821 8y ago

What's in it for these companies? Seems like there must be a catch