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Let's walk through this: People who are insomniacs are more likely to get less sleep. Could this same group also more likely to take anticholinergic sleep drugs
by notaharvardmba 8y ago
Let's walk through this: People who are insomniacs are more likely to get less sleep. Could this same group also more likely to take anticholinergic sleep drugs (diphenhydramine)? There is a good link starting to be established between those drugs and dementias of all types. See https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2091745 https://jamanetwork.com/journals/jamainternalmedicine/fullar..., or a bloggy summary if you're so inclined: https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667 https://www.health.harvard.edu/blog/common-anticholinergic-d...
The link is alarming enough you should think seriously before taking things like Zzzquil, Benadryl, Tylenol PM, etc. if you value your mental faculties.. But maybe the correlation in this article is at least partially explained by this other link. Personally the other theories (brain garbage collection during sleep, etc.) also make a lot of sense. And don't forget about the fungal theory: https://www.ncbi.nlm.nih.gov/pubmed/24614898 https://www.ncbi.nlm.nih.gov/pubmed/24614898
- lucidone 8y agoI don't have much to add, but I know some of these drugs (ie DPH) are serious deliriants at high doses. It causing a loss of mental faculties with long term use would not surprise me.
- toast0 8y agoDiphenhydramine is an anti-hystimine, that happens to make you drowsy (it's also a mild anti-depresent, which lead to somr targetted anti-depresents).
- loa-in-backup 8y agoI guess it's a complex organic molecule with multiple interactions