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Research chemicals are dangerous. They’re mostly all synthetics derived from amphetamine class of drugs like MDMA. 2CE. 2CB. 2CI. Etc. and countless others. N

Research chemicals are dangerous. They’re mostly all synthetics derived from amphetamine class of drugs like MDMA. 2CE. 2CB. 2CI. Etc. and countless others. No one taking them know what it truly is. They are dangerous. And more ubiquitous than LSD-25. You can never be sure what you’re getting. You can OD and have a psychotic episode. I do not classify them as therapeutic psychedelics, and always advise against. If you ever take a tab of LSD and it’s bitter or metallic, or anything but absolutely flavorless or just paper, do not take. Spit it out.

samatman 8y ago
This is an idiosyncratic opinion to say the least. 2C-E, 2C-B, and 2C-I are what they are, single compounds, just as LSD-25 is. They are phenethylamines, related to mescaline, the substance for which the term "psychedelic" was coined. They are synthetic, as is LSD, and have a wide therapeutic index. Being less potent by weight, it is easier to measure a specific dose than with LSD, which is commonly put on paper or taken in liquid form. Getting "puddled" from a bottle of LSD is a more likely route to a psychotic episode than anything 2C-I or 2C-B have to offer; 2C-E is a different beast. It's fine that you have these opinions, I guess. It's just that most of them are wrong and I wouldn't want others to be mislead.
throwaaaay 8y ago
Anecdotally I’ve consumed 50-75 100mcg doses of 1P-LSD over the last year and found it almost indistinguishable from LSD. Not to mention easier and safer to obtain (directly from a research lab). Obviously there is no research on long term effects at this point, and there may never be, but for my personal therapeutic rituals it’s affectiveness is the same. It’s also worth noting that I’m not microdosing, which you may have assumed from my doses over time. I’m taking it once a week at an average dose of 300-600mcg with a 1-2 week break every 4 weeks (obviously I didn’t start at this dose when I first tried it). Along with other health supplements and exercise just so were clear. I am an experienced psychonaut, but I’m not a doctor, and I’m not here to champion 1P-LSD nor my personal rituals. But this is my experience.
- Aspyre 8y ago
  Cool! Glad to see mention of 1P here. I'm a fan of it myself.
- tibbon 8y ago
  Isn't 1P-LSD the ones that metabolizes into LSD-25?
  - throwaaaay 8y ago
    AFAIK it has not been proven if it breaks down into lsd-25 of if 1p itself fits into the 5-ht receptor as it’s own in vivo. >It has been theorized that 1P-LSD may act as a prodrug for LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo.[1] Otherwise, it is possible that 1P-LSD may be capable of exerting its own psychedelic effect. https://psychonautwiki.org/wiki/1P-LSD https://psychonautwiki.org/wiki/1P-LSD
orasis 8y ago
The really dangerous stuff is the NBOMEs which were being sold as LSD maybe 7 years ago. This is why we need legalization, so people can be sure what they're getting.
nbardy 8y ago
This is a bit reductions. There is a lot of research chemicals that are very safe analogues, e.g. 4-ACO-DMT or 1P-LSD. Often times more safe because when you purchase these its from a lab that does testing and you know exactly what you're getting. The real danger of Research Chemicals is the large amount of cheap drugs of other classes produced that have similar effects and are labeled and sold as LSD. Very few people are buying those type of drugs and taking them on purpose. And they are incredibly dangerous.
Nursie 8y ago
This seems to me to be a very dogmatic approach. One can be sure of what one is getting with proper testing. Some are dangerous, others less so. Personally I enjoyed my experiences with some of them.
yeahforsureman 8y ago
Although far from non-existent, none of the chemicals you list are more ubiquitous than acid nor usually sold as acid. Actually, their effective dose range is about 100x that of acid and it would be hard to impossible to fit them on a tab. NBOMEs are something you did see sold as acid especially a few years back, so I'm not saying you shouldn't be careful. The difference in effect is fairly easy to tell, though, and I have no doubt most stuff sold is the real thing. There are some closely related and nearly indistinguishable compounds, but as far as I know, they are about as hard to synthesize and should have a similar risk profile as LSD.
bfuller 8y ago
>And more ubiquitous than LSD-25. that is CERTAINLY false.
tibbon 8y ago
It's worth noting that people can know what they are taking (within a statistical certainly) by sending their substances off to somewhere like Energy Control, or another analytical lab for testing. Most people don't do it, but it is possible to know what you've got. https://energycontrol-international.org/ https://energycontrol-international.org/

samatman 8y ago

This is an idiosyncratic opinion to say the least. 2C-E, 2C-B, and 2C-I are what they are, single compounds, just as LSD-25 is. They are phenethylamines, related to mescaline, the substance for which the term "psychedelic" was coined. They are synthetic, as is LSD, and have a wide therapeutic index. Being less potent by weight, it is easier to measure a specific dose than with LSD, which is commonly put on paper or taken in liquid form. Getting "puddled" from a bottle of LSD is a more likely route to a psychotic episode than anything 2C-I or 2C-B have to offer; 2C-E is a different beast. It's fine that you have these opinions, I guess. It's just that most of them are wrong and I wouldn't want others to be mislead.

throwaaaay 8y ago

Anecdotally I’ve consumed 50-75 100mcg doses of 1P-LSD over the last year and found it almost indistinguishable from LSD. Not to mention easier and safer to obtain (directly from a research lab). Obviously there is no research on long term effects at this point, and there may never be, but for my personal therapeutic rituals it’s affectiveness is the same. It’s also worth noting that I’m not microdosing, which you may have assumed from my doses over time. I’m taking it once a week at an average dose of 300-600mcg with a 1-2 week break every 4 weeks (obviously I didn’t start at this dose when I first tried it). Along with other health supplements and exercise just so were clear. I am an experienced psychonaut, but I’m not a doctor, and I’m not here to champion 1P-LSD nor my personal rituals. But this is my experience.

Aspyre 8y ago
Cool! Glad to see mention of 1P here. I'm a fan of it myself.
tibbon 8y ago
Isn't 1P-LSD the ones that metabolizes into LSD-25?
- throwaaaay 8y ago
  AFAIK it has not been proven if it breaks down into lsd-25 of if 1p itself fits into the 5-ht receptor as it’s own in vivo. >It has been theorized that 1P-LSD may act as a prodrug for LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo.[1] Otherwise, it is possible that 1P-LSD may be capable of exerting its own psychedelic effect. https://psychonautwiki.org/wiki/1P-LSD https://psychonautwiki.org/wiki/1P-LSD

orasis 8y ago

The really dangerous stuff is the NBOMEs which were being sold as LSD maybe 7 years ago. This is why we need legalization, so people can be sure what they're getting.

nbardy 8y ago

This is a bit reductions. There is a lot of research chemicals that are very safe analogues, e.g. 4-ACO-DMT or 1P-LSD. Often times more safe because when you purchase these its from a lab that does testing and you know exactly what you're getting. The real danger of Research Chemicals is the large amount of cheap drugs of other classes produced that have similar effects and are labeled and sold as LSD. Very few people are buying those type of drugs and taking them on purpose. And they are incredibly dangerous.

Nursie 8y ago

This seems to me to be a very dogmatic approach. One can be sure of what one is getting with proper testing. Some are dangerous, others less so. Personally I enjoyed my experiences with some of them.

yeahforsureman 8y ago

Although far from non-existent, none of the chemicals you list are more ubiquitous than acid nor usually sold as acid. Actually, their effective dose range is about 100x that of acid and it would be hard to impossible to fit them on a tab. NBOMEs are something you did see sold as acid especially a few years back, so I'm not saying you shouldn't be careful. The difference in effect is fairly easy to tell, though, and I have no doubt most stuff sold is the real thing. There are some closely related and nearly indistinguishable compounds, but as far as I know, they are about as hard to synthesize and should have a similar risk profile as LSD.

bfuller 8y ago

>And more ubiquitous than LSD-25. that is CERTAINLY false.

tibbon 8y ago

It's worth noting that people can know what they are taking (within a statistical certainly) by sending their substances off to somewhere like Energy Control, or another analytical lab for testing. Most people don't do it, but it is possible to know what you've got. https://energycontrol-international.org/ https://energycontrol-international.org/