4 ms·

Well, we could work on a cure and vaccine for HSV-1. Whether or not it mitigates Alzheimer's I sure would pay a lot of money to not deal with cold sores every w

by jopsen 8y ago

Well, we could work on a cure and vaccine for HSV-1. Whether or not it mitigates Alzheimer's I sure would pay a lot of money to not deal with cold sores every winter.

yakshaving_jgt 8y ago
There already is an effective therapeutic vaccine. There has been for years. The problem is, it's only done a phase II clinic trial. They need USD$20mm to move through the third phase, and onto mass production. The company is called AuRx. If anyone has twenty million in their pocket, please end herpes for all. Peter Thiel's investment firm threw USD$7mm at Rational Vaccines last year, but unfortunately as far as I'm aware they are mired in a legal battle since their first human "clinical trial" was performed outside the supervision of the regulators. Rational Vaccines (Prof. William Halford) developed Theravax, a live-attenuated vaccine. It operates on the same principle as the vaccine developed by AuRx, but IIRC, not quite as safely and effectively. Aside from this, our only (as far as I'm aware) hopes are CRISPR efforts from either Editas or Excision Bio, or an antiviral developed by NanoViricides.
- echelon 8y ago
  Have they thought about crowd funding a raise? I'd contribute. Surely they can do something outside of institutional investing.
  - yakshaving_jgt 8y ago
    Yeah, there have been many attempts at crowdfunding this stuff. As it turns out, nobody cares that much. You'd think all the celebrities who buy $100mm mansions could do something about it (since statistically they probably all have it), but no. If we're lucky, Thiel's investment will turn good. I'm sure his associates aren't morons and they didn't invest in a dud. Last I heard, Rational Vaccines are ramping up to proper human clinic trials within FDA regulations. We just need to wait. Excision Bio should be running human clinical trials either next year or the following, and our collective understanding of CRISPR is expanding rapidly. So that's something to be excited about. Not that this makes waiting any less painful for sufferers.
    - delbel 8y ago
      wait, hold on. there's an effective drug that cures HHV-1 and alot of other things include the cryptoplasma cat parasite virus, and Herpies 2. There's no toxic limit (people take 4g twice a day with no side effect, way over what is needed to kill it) and it works within 48-72 hours. We don't need a vaccine. It could be sold over the counter. There are two groups that have separate method of actions, so if it fails there's another one.
      - yakshaving_jgt 8y ago
        This is categorically false. There is no cure for HSV. The current state of care is periodic retroactive therapy in the case of an outbreak, or continuous prophylaxis which isn't completely effective due to lack of bioavailability. People still get outbreaks during prophylaxis, and people still shed the virus when symptoms aren't present.
        delbel 8y ago
        if your a doctor I'll send you the name of the drugs. They came out in 2015 and are about $80 each a pill, but you can buy them in India for $.34 each.
        yakshaving_jgt 8y ago
        I am not a doctor, just a relatively informed individual. I believe the drug you are talking about is Pritelivir/Amenamevir, currently marketed in Japan under the name Amenalief. Am I correct? If so, I was not aware they are available in India for such a low price.

by jopsen 8y ago

Well, we could work on a cure and vaccine for HSV-1. Whether or not it mitigates Alzheimer's I sure would pay a lot of money to not deal with cold sores every winter.

yakshaving_jgt 8y ago

There already is an effective therapeutic vaccine. There has been for years. The problem is, it's only done a phase II clinic trial. They need USD$20mm to move through the third phase, and onto mass production. The company is called AuRx. If anyone has twenty million in their pocket, please end herpes for all. Peter Thiel's investment firm threw USD$7mm at Rational Vaccines last year, but unfortunately as far as I'm aware they are mired in a legal battle since their first human "clinical trial" was performed outside the supervision of the regulators. Rational Vaccines (Prof. William Halford) developed Theravax, a live-attenuated vaccine. It operates on the same principle as the vaccine developed by AuRx, but IIRC, not quite as safely and effectively. Aside from this, our only (as far as I'm aware) hopes are CRISPR efforts from either Editas or Excision Bio, or an antiviral developed by NanoViricides.

echelon 8y ago
Have they thought about crowd funding a raise? I'd contribute. Surely they can do something outside of institutional investing.
- yakshaving_jgt 8y ago
  Yeah, there have been many attempts at crowdfunding this stuff. As it turns out, nobody cares that much. You'd think all the celebrities who buy $100mm mansions could do something about it (since statistically they probably all have it), but no. If we're lucky, Thiel's investment will turn good. I'm sure his associates aren't morons and they didn't invest in a dud. Last I heard, Rational Vaccines are ramping up to proper human clinic trials within FDA regulations. We just need to wait. Excision Bio should be running human clinical trials either next year or the following, and our collective understanding of CRISPR is expanding rapidly. So that's something to be excited about. Not that this makes waiting any less painful for sufferers.
  - delbel 8y ago
    wait, hold on. there's an effective drug that cures HHV-1 and alot of other things include the cryptoplasma cat parasite virus, and Herpies 2. There's no toxic limit (people take 4g twice a day with no side effect, way over what is needed to kill it) and it works within 48-72 hours. We don't need a vaccine. It could be sold over the counter. There are two groups that have separate method of actions, so if it fails there's another one.
    - yakshaving_jgt 8y ago
      This is categorically false. There is no cure for HSV. The current state of care is periodic retroactive therapy in the case of an outbreak, or continuous prophylaxis which isn't completely effective due to lack of bioavailability. People still get outbreaks during prophylaxis, and people still shed the virus when symptoms aren't present.
      - delbel 8y ago
        if your a doctor I'll send you the name of the drugs. They came out in 2015 and are about $80 each a pill, but you can buy them in India for $.34 each.
        yakshaving_jgt 8y ago
        I am not a doctor, just a relatively informed individual. I believe the drug you are talking about is Pritelivir/Amenamevir, currently marketed in Japan under the name Amenalief. Am I correct? If so, I was not aware they are available in India for such a low price.