Your article was an excellent read, so thanks for the link. I generally agree with a lot of what you're saying. My potential audience is pretty targeted - main

Your article was an excellent read, so thanks for the link. I generally agree with a lot of what you're saying. My potential audience is pretty targeted - mainly research scientists and possibly some government workers. They'll likely be more computer savvy than the average user (on average, at least - some scientists I know are just as bad as Grandma.) What I worry about in considering a web app is: 1 - People want to be able to run the software anywhere, any time, without a connection to the internet. 2 - When entering large amounts of data, which is potentially sensitive, into an application, it seems like people would trust a desktop app more. Number 2 is subjective, but as a scientist myself, I would feel better about a program running on my own machine. Any thoughts?