3 ms·
I don't think it has the same binding affinity as more powerful opiods which reduces it's addictive potential, as well the risk of overdose.
by JamesBarney 8y ago
I don't think it has the same binding affinity as more powerful opiods which reduces it's addictive potential, as well the risk of overdose.
- __blockcipher__ 8y agoIt activates mu-opioid quite strongly but not the other receptors as much (I forget their names). Interestingly, it has a mix of opioid antagonists and agonists. I’m not sure if that specifically is why tolerance doesn’t build aggressively, or if it’s some other MoA like nmda receptor antagonism