I think you should completely wrap your head around JavaScript's prototype chain before learning anything else. Since you are coming from Python the Javascript

I think you should completely wrap your head around JavaScript's prototype chain before learning anything else. Since you are coming from Python the Javascript objects will be a bit of a shock. and regardless of the framework you choose you will have encounters with this strange Javascript inheritance (like angular 1 $scopes used it). Personally I would recommend Vue once you're ready because you can get started with it right away. Also like others said learning webpack, npm will be really beneficial.