I would avoid frameworks but embrace transpiling and popular libraries. es6katas.org is a nice starting point for newish es6 to look up in MDN. After a couple

I would avoid frameworks but embrace transpiling and popular libraries. es6katas.org is a nice starting point for newish es6 to look up in MDN. After a couple years any es you are transpiling now will be usable directly on websites so you then have more of a choice in direction. Frameworks might not be any more stable in another 2 years but adapting with them is much easier as you know more modern js.