Interstate and major highway signage in the US is really pretty good. And state/region level maps a great for getting around on them. The main problem is, if

Interstate and major highway signage in the US is really pretty good. And state/region level maps a great for getting around on them. The main problem is, if I'm on a motorcycle trip I want to spend as little time on those roads as possible. It's difficult to manage enough maps to get at "the good stuff" on a long ride - but a decent GPS will get you details quickly, and deals well with the highly variable signage once you are on secondary highways and tertiary roads. I think the best bet is a mix of both plus, for me, significant time spent in pure explore mode (no map at all). That's not for everyone I suppose but I've had some of my best travel days navigating by little more than the sun and major features.