>'"the" amyloid hypothesis (again, it's a family of hypotheses because each drug has a different intended mechanism of action and is therefore a different testa

>'"the" amyloid hypothesis (again, it's a family of hypotheses because each drug has a different intended mechanism of action and is therefore a different testable hypothesis) has been the only workable theory of how the disease works.' Afaict, there was nothing especially workable about it vs eg the "cholinergic hypothesis". In fact the only drugs that are said to help were devised based on that hypothesis.[1] So something else is going on here. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956752/