4 ms·
What made it so previously unthinkable? Admitting you have invested twenty years of research and you're not an inch closer- in fact you went down the wrong pat
by st26 8y ago
What made it so previously unthinkable?
Admitting you have invested twenty years of research and you're not an inch closer- in fact you went down the wrong path entirely- would be a pretty bitter pill to swallow, both for researchers and patients.
- nonbel 8y agoSo some sort of critical mass was hit after x years and if that bet was wrong they are doomed for the next 20-40? Why didn't they wait until an actual definitive prediction came true?
- db48x 8y agoNobody understand the brain well enough to do that yet. Furthermore, the existence of a cure for a disease goes a long way towards proving what the mechanism of the disease is.
- nonbel 8y ago>"Nobody understand the brain well enough to do that yet." I'm fairly certain I understand the brain well enough to know our understanding of the brain is rudimentary and there is no reason to become attached to a vague preliminary model like this "amyloid hypothesis".
- db48x 8y agoIt's not so vague as it might sound. There's good evidence that people with amyloid plaque build-up, in the brain or in other organs, have different versions of the genes that code for the production of amyloid proteins than people who do not.