3 ms·

This is far from the whole story. The pathology of alzheimers as predicted by the Amyloid Hypothesis is (year 0) imbalance in the production, (year 10-30) depos

This is far from the whole story. The pathology of alzheimers as predicted by the Amyloid Hypothesis is (year 0) imbalance in the production, (year 10-30) deposition of abeta causes Tau and other downstream complications that are symptomatic. Existing clinical studies started way too late, after the appearance of significant sympthoms - at least mild cognitive impairment. Personally, i take curcumin supplements, as it is known to bind to abeta even in the cerebrospinal fluid, then it gets cleared out over the blood brain barrier. If the abeta hypothesis is true, high dose curcumin should help delay its onset. Another thing to do is get your genome sequenced, even with 23andme. If you have apoe4, you should, IMO, take curcumin.

exhilaration 8y ago
Would you mind sharing which curcumin supplements you take? I'm currently taking one 750mg capsule of curcumin per day but I've been considering switching to theracurmin after reading about it in Hacker News comments.
- jamesblonde 8y ago
  I take biocurcumax. Curcumin with bioperine is also good - i wouldn't take theracurmin, though. Afaik, it has lots of downstream curcumin metabolites, and they aren't anti-inflammatory/abeta-binding.
nonbel 8y ago
Fyi, I have no idea if your regimen (or any) of curcumin is good for you or not but amyloid beta may be protective in some way: >"Mice with excess beta-amyloid survived longer than the controls and had less bacteria in their brains. Mice lacking beta-amyloid (from the genetic removal of APP) died more often from infection." https://www.nih.gov/news-events/nih-research-matters/alzheimers-protein-may-have-natural-antibiotic-role https://www.nih.gov/news-events/nih-research-matters/alzheim...
- jamesblonde 8y ago
  Curcumin won't clear out all abeta. Just bind to some and clear it. It also dampens anti-inflammatory pathways (e.g., mild inhibitor of TNF-alpha production). I see the cost-benefit being overall positive for medium-dose curcumin (like 500mg-1g/day).
  - nonbel 8y ago
    What are you basing any of this on? How much benefit are you receiving for what cost? How do you know you aren't a "low abeta" individual?
  - tim333 8y ago
    There is quite a lot of somewhat fuzzy evidence for curcumin helping eg. this https://www.telegraph.co.uk/science/2016/05/20/eating-curry-may-help-fight-off-dementia-new-study-suggests/ https://www.telegraph.co.uk/science/2016/05/20/eating-curry-... > 96 participants aged between 40 and 90 over 12 months. >In tests of verbal and memory skills, those taking the dummy pill suffered a decline in mental function after just six months that was not observed in those who took curcumin At least it has no negative side effect and tastes good in its chicken korma form.

exhilaration 8y ago

Would you mind sharing which curcumin supplements you take? I'm currently taking one 750mg capsule of curcumin per day but I've been considering switching to theracurmin after reading about it in Hacker News comments.

jamesblonde 8y ago
I take biocurcumax. Curcumin with bioperine is also good - i wouldn't take theracurmin, though. Afaik, it has lots of downstream curcumin metabolites, and they aren't anti-inflammatory/abeta-binding.

nonbel 8y ago

Fyi, I have no idea if your regimen (or any) of curcumin is good for you or not but amyloid beta may be protective in some way: >"Mice with excess beta-amyloid survived longer than the controls and had less bacteria in their brains. Mice lacking beta-amyloid (from the genetic removal of APP) died more often from infection." https://www.nih.gov/news-events/nih-research-matters/alzheimers-protein-may-have-natural-antibiotic-role https://www.nih.gov/news-events/nih-research-matters/alzheim...

jamesblonde 8y ago
Curcumin won't clear out all abeta. Just bind to some and clear it. It also dampens anti-inflammatory pathways (e.g., mild inhibitor of TNF-alpha production). I see the cost-benefit being overall positive for medium-dose curcumin (like 500mg-1g/day).
- nonbel 8y ago
  What are you basing any of this on? How much benefit are you receiving for what cost? How do you know you aren't a "low abeta" individual?
- tim333 8y ago
  There is quite a lot of somewhat fuzzy evidence for curcumin helping eg. this https://www.telegraph.co.uk/science/2016/05/20/eating-curry-may-help-fight-off-dementia-new-study-suggests/ https://www.telegraph.co.uk/science/2016/05/20/eating-curry-... > 96 participants aged between 40 and 90 over 12 months. >In tests of verbal and memory skills, those taking the dummy pill suffered a decline in mental function after just six months that was not observed in those who took curcumin At least it has no negative side effect and tastes good in its chicken korma form.