5 ms·

Frightening thought: if (at least some cases of) Alzheimer's really is something akin to "Type III Diabetes", the planet and especially the USA can expect absol

by themgt 8y ago

Frightening thought: if (at least some cases of) Alzheimer's really is something akin to "Type III Diabetes", the planet and especially the USA can expect absolutely skyrocketing numbers as today's obese adults age. [1] https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-is-alzheimers-type-3-diabetes/ https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-mi... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/

LinuxBender 8y ago
If T2D can be reversed with fasting (to purge the pancreas of fat), does that mean we could test things like Acetyle-L-Carnitine in larger dosages in the brain to affect T3D? Or perhaps a variant of 2-hydroxypropyl-beta-cyclodextrin? Has anyone tried experimenting in this area? Or is this a viral condition as others in the thread have mentioned? Perhaps these are not mutually exclusive?
- trendia 8y ago
  The amyloid, T3D, and viral hypotheses still don't explain why cholesterol, obesity, air pollution, lack of sleep, and sedentary liftestyle positively correlate with Alzheimer's and high caffeine intake and regular exercise negatively correlate with it.
  - subcosmos 8y ago
    They do, if you consider the recent findings that many viruses have evolved to exploit our colesterol synthesis and transport machinery to spread, it becomes clear that many diseases of aging may have a viral cause : https://medium.com/@InfinoMe/senescence-links-between-heart-disease-genomics-and-aging-fa78bde773da https://medium.com/@InfinoMe/senescence-links-between-heart-... Rhinovirus, the cause of the common cold, binds to vLDL receptors. vLDL incidentally being the primary risk factor for cardiovascular disease https://www.ncbi.nlm.nih.gov/pubmed/12857919 https://www.ncbi.nlm.nih.gov/pubmed/12857919 Influenza requires the cholesterol transport system to bud and spread http://news.mit.edu/2017/cholesterol-helps-flu-virus-escape-through-host-cell-membrane-1120 http://news.mit.edu/2017/cholesterol-helps-flu-virus-escape-... Hepatitis C virus relies on APO-E, our favorite alzheimers gene, to flourish, and APO-E genotype predicts if you will get liver cancer from Hep-B https://goo.gl/images/Hev5ev https://goo.gl/images/Hev5ev T2D, CVD, and obesity, being characterized by hypercholesterolemia and mitochondrial dysfunction, are illnesses that are supportive of viral infections. They also promote AGE formation, which activates the innate immune system through a variety of RAGE receptors, Galectin-3 being potentially a central axis as it is also part of the senescent phenotype.
    - trendia 8y ago
      In the context of the infectious disease hypothesis, do you know why caffeine / coffee would be associated with lower incidence of Alzheimer's? (It reduces amyloid-beta levels, but if plaques are not the cause of Alzheimer's then this shouldn't provide any protective benefit)
      - subcosmos 8y ago
        It's ongoing work for me. Lately I've been digging through a lot of gene expression datasets to try and figure out which genes are the most overexpressed in aging tissues. I then use bioinformatics tools like clue.io to figure out which OTHER genes regulate them, and also possible drugs. There are a number of pathways that seem to be downregulated by purigenic receptors, many of which are sensitive to adenosine. Caffeine blocks adenosine receptors and blocks signaling. What could be happening here is suppressing inflammation, since evidently purine nucleotides activate some immune cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568887/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568887/
        nonbel 8y ago
        Its not difficult to come up with mechanisms like that, not even difficult to come up with the idea and then get some evidence consistent with it. The key is to make sure everything works out quantitatively: https://www.ncbi.nlm.nih.gov/pubmed/12242150 https://www.ncbi.nlm.nih.gov/pubmed/12242150
        ishwarn 8y ago
        So this theory holds for caffeine, not specifically coffee? I'm not sure why, but I was under the impression that it was specifically coffee that could be tied to lower incidence of Alzheimers.
        mrfusion 8y ago
        Can’t it be as simple as caffeine boosts your metabolism and mutes blood sugar spikes?
    - 8y ago
aszantu 8y ago
There was some youtube where some doc connects the alzheimers of the babyboomers to heart or sugar medication, can't remember <_< too much information out there
- hermitdev 8y ago
  Well, to be fair, if you eliminate the common causes of death, other, new, common causes will crop up. At the start of the babyboomer generation, small pox & polio were being wiped out, so it's natural that something else came in to take its place. Hell, cancer likely wasn't a great common killer even a century ago until people started living long enough to experience it. I'm not trying to hand wave over anything, but it's hard to justify comparing cause of death stats from nearly 100 years ago to current era when we've made so many strides in combating some previously fatal diseases that are now routinely treatable or even preventable. Alzheimer's sucks. Dementia sucks. I've worked for/with people with Alzheimer's and it's never pretty. I lost my own Grandfather to dementia last year. Neither is pretty, and the both do the same damage: typically the person suffering from the disease isn't even aware, but all family and close associates suffer instead. It's brutal to all involved.
tiatia123 8y ago
Insulin improves AD, if applied intranasal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709085/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709085/
Madmallard 8y ago
I think it'll increase in prevalence among other dementias just because of the rise in dna mutations that are viable for survival in modern society
rabboRubble 8y ago
Exactly why I'm trying to eat zero added sugar. Many days I fail, but overall I'm eating less. I put it in the "can't hurt" bucket.

by themgt 8y ago

LinuxBender 8y ago

If T2D can be reversed with fasting (to purge the pancreas of fat), does that mean we could test things like Acetyle-L-Carnitine in larger dosages in the brain to affect T3D? Or perhaps a variant of 2-hydroxypropyl-beta-cyclodextrin? Has anyone tried experimenting in this area? Or is this a viral condition as others in the thread have mentioned? Perhaps these are not mutually exclusive?

trendia 8y ago
The amyloid, T3D, and viral hypotheses still don't explain why cholesterol, obesity, air pollution, lack of sleep, and sedentary liftestyle positively correlate with Alzheimer's and high caffeine intake and regular exercise negatively correlate with it.
- subcosmos 8y ago
  They do, if you consider the recent findings that many viruses have evolved to exploit our colesterol synthesis and transport machinery to spread, it becomes clear that many diseases of aging may have a viral cause : https://medium.com/@InfinoMe/senescence-links-between-heart-disease-genomics-and-aging-fa78bde773da https://medium.com/@InfinoMe/senescence-links-between-heart-... Rhinovirus, the cause of the common cold, binds to vLDL receptors. vLDL incidentally being the primary risk factor for cardiovascular disease https://www.ncbi.nlm.nih.gov/pubmed/12857919 https://www.ncbi.nlm.nih.gov/pubmed/12857919 Influenza requires the cholesterol transport system to bud and spread http://news.mit.edu/2017/cholesterol-helps-flu-virus-escape-through-host-cell-membrane-1120 http://news.mit.edu/2017/cholesterol-helps-flu-virus-escape-... Hepatitis C virus relies on APO-E, our favorite alzheimers gene, to flourish, and APO-E genotype predicts if you will get liver cancer from Hep-B https://goo.gl/images/Hev5ev https://goo.gl/images/Hev5ev T2D, CVD, and obesity, being characterized by hypercholesterolemia and mitochondrial dysfunction, are illnesses that are supportive of viral infections. They also promote AGE formation, which activates the innate immune system through a variety of RAGE receptors, Galectin-3 being potentially a central axis as it is also part of the senescent phenotype.
  - trendia 8y ago
    In the context of the infectious disease hypothesis, do you know why caffeine / coffee would be associated with lower incidence of Alzheimer's? (It reduces amyloid-beta levels, but if plaques are not the cause of Alzheimer's then this shouldn't provide any protective benefit)
    - subcosmos 8y ago
      It's ongoing work for me. Lately I've been digging through a lot of gene expression datasets to try and figure out which genes are the most overexpressed in aging tissues. I then use bioinformatics tools like clue.io to figure out which OTHER genes regulate them, and also possible drugs. There are a number of pathways that seem to be downregulated by purigenic receptors, many of which are sensitive to adenosine. Caffeine blocks adenosine receptors and blocks signaling. What could be happening here is suppressing inflammation, since evidently purine nucleotides activate some immune cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568887/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568887/
      - nonbel 8y ago
        Its not difficult to come up with mechanisms like that, not even difficult to come up with the idea and then get some evidence consistent with it. The key is to make sure everything works out quantitatively: https://www.ncbi.nlm.nih.gov/pubmed/12242150 https://www.ncbi.nlm.nih.gov/pubmed/12242150
      - ishwarn 8y ago
        So this theory holds for caffeine, not specifically coffee? I'm not sure why, but I was under the impression that it was specifically coffee that could be tied to lower incidence of Alzheimers.
      - mrfusion 8y ago
        Can’t it be as simple as caffeine boosts your metabolism and mutes blood sugar spikes?
  - 8y ago

aszantu 8y ago

There was some youtube where some doc connects the alzheimers of the babyboomers to heart or sugar medication, can't remember <_< too much information out there

hermitdev 8y ago
Well, to be fair, if you eliminate the common causes of death, other, new, common causes will crop up. At the start of the babyboomer generation, small pox & polio were being wiped out, so it's natural that something else came in to take its place. Hell, cancer likely wasn't a great common killer even a century ago until people started living long enough to experience it. I'm not trying to hand wave over anything, but it's hard to justify comparing cause of death stats from nearly 100 years ago to current era when we've made so many strides in combating some previously fatal diseases that are now routinely treatable or even preventable. Alzheimer's sucks. Dementia sucks. I've worked for/with people with Alzheimer's and it's never pretty. I lost my own Grandfather to dementia last year. Neither is pretty, and the both do the same damage: typically the person suffering from the disease isn't even aware, but all family and close associates suffer instead. It's brutal to all involved.

tiatia123 8y ago

Insulin improves AD, if applied intranasal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709085/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709085/

Madmallard 8y ago

I think it'll increase in prevalence among other dementias just because of the rise in dna mutations that are viable for survival in modern society

rabboRubble 8y ago

Exactly why I'm trying to eat zero added sugar. Many days I fail, but overall I'm eating less. I put it in the "can't hurt" bucket.