3 ms·
Sadly, no mention of microglia as a possible cause. I can't explain it myself, but someone who was close to me was researching this extensively and was often fr
by tibbon 8y ago
Sadly, no mention of microglia as a possible cause. I can't explain it myself, but someone who was close to me was researching this extensively and was often frustrated by the over-focus on amyloid.
- jayzee44 8y agoI agree. Microglia should be where a lot of the focus should be moving. From my limited recent research on microglia and AD, it seems that plaque build up is actually a symptom that is perhaps caused by dysfunctional microglia, which normally phagocytoze plaques when functioning properly. Microglia secrete all kinds of neurotoxins and cytokines that mediate the inflammatory response. It is highly plausible that progressive damage to microglial function induces a pathological state where the microglia become destructive to the neuronal enivronment.