I think Ram Shriram's Google investment was probably better. Here is a list of some more http://www.suite101.com/content/greatest-venture-capital-investments-ev

I think Ram Shriram's Google investment was probably better. Here is a list of some more http://www.suite101.com/content/greatest-venture-capital-investments-ever-electricity-and-google-a257793 http://www.suite101.com/content/greatest-venture-capital-inv.... Also, there is some debate over the $24 the dutch bought Manhattan for from the Indians. Jury is still out on that one.