As an ambidextrous-enough person (lefty for a lot of things but write right-handed), for a while my preferred computer setup was a mouse on the left—buttons not

As an ambidextrous-enough person (lefty for a lot of things but write right-handed), for a while my preferred computer setup was a mouse on the left—buttons not swapped, so primary click was on the (stronger) middle finger and right-click/scroll was on the (literally more dexterous) index finger—and a drawing tablet on the right, since I was doing a lot of digital design/painting. Having two pointing devices, one relative and one absolute, felt really useful, as if I could really get in there and manipulate the computer more directly & precisely. Dunno if that was just my perception or if it actually made me any defter. Nowadays I just use the touchpad on my MBP.