Django is by far the best full-stack MVC solution IMO. It is well known in python communities, and python is growing in popularity year over year. As for your

Django is by far the best full-stack MVC solution IMO. It is well known in python communities, and python is growing in popularity year over year. As for your javascript questions: React is the answer. Not just because it has the considerable resources of Facebook backing it, but because at it's core, the idea is extremely sound and well tested, going back 30 or more years. Vue.js has similar principles and might also be a good choice, but what you need to look out for is the community surrounding it, and whether it will eventually be unsupported. Node.js is great in the backend, but doesn't have quite as many mature frameworks like Django. If you're down to build things from bare metal using some libraries like Express.js or Koa.js, then you'll enjoy Node.js. Typescript and Flow have also made Node more attractive.