First, ISA refers to a particular kind of hardware interface. I have never heard ISA refer to the Wintel duopoly. Second, there actually is a reason to stick

First, ISA refers to a particular kind of hardware interface. I have never heard ISA refer to the Wintel duopoly. Second, there actually is a reason to stick with Intel when it comes to fabbing - only Intel and a few other large players can deliver 45nm process. As long as Intel has the lead on process technology their chips will almost always be faster. Multiple cores - maybe. DSP-like or 3D acceleration in hardware - more likely.