For sites that have a lot of content, you can just do a fluid layout that looks good at any resolution. Keep in mind, it won't look good at higher resolutions i

For sites that have a lot of content, you can just do a fluid layout that looks good at any resolution. Keep in mind, it won't look good at higher resolutions if there is too much open space. I have a few sites that look great on everything from a phone to a television screen. If you properly float elements, they will take up horizontal space when they can and go to the next line when they can't.