Does this mean companies need to file 50 different state returns? How can any company other than a mega-corporation be expected to handle that level of bureauc

Does this mean companies need to file 50 different state returns? How can any company other than a mega-corporation be expected to handle that level of bureaucracy? Even if their are firms that pop up to handle compliance it's probably going to cost a fortune. This will put a huge strain on small companies forcing many of them out of business.