This is basically what it is : basic systems theory applied to basic genetic knowledge. Having worked in this field during my studies, I can say that most of th

This is basically what it is : basic systems theory applied to basic genetic knowledge. Having worked in this field during my studies, I can say that most of the leading figures were not impressed by the Omnigenics paper. It was simply the right claim at the right time, it made a splash, but it will probably not change at all how research is conducted. Some say that the view it is pushing (core vs peripheral genes) is simply wrong as evidence of it cannot be found in the data (and there is a lot of data), see the end of the article about Naomi Wray's article. Also see the many mentions of the paper's critics! I like the phrase "provocatively phrased extension of earlier ideas". There are bigger issues that need addressing but all of them are much much harder to get right and they would probably not make it to Quanta magazine ;) For example, phenotype heterogeneity and patient stratification are two big thorns in precision medicine's side.