They can do similar things, uBlock Origin is setup to block ads and other elements on the page (depending on the lists you subscribe to). But uMatrix is more l

They can do similar things, uBlock Origin is setup to block ads and other elements on the page (depending on the lists you subscribe to). But uMatrix is more like Noscript, it's blocking the loading of resources from the web. So you can block javascript from some domains, while allowing images or video, etc. I use both so i can block a lot of third party scripts even without them being ads (so most tracking scripts and such).