> AFAIK, the biggest problem with GHB is its synergy with alcohol. Most GHB related deaths also involve alcohol. That's a good point. I had forgotten that base

> AFAIK, the biggest problem with GHB is its synergy with alcohol. Most GHB related deaths also involve alcohol. That's a good point. I had forgotten that base assumption in the club scene, though it was generally much less of an issue in the rave scene, at least during the 90s. > GHB therapeutic index (8) Thanks. Do you have a reference for that? How does that number change with two standard drinks on board? > is just slightly lower than alcohol (10). One of the other properties of alcohol that could make it more difficult to reach a lethal OD, which I already mentioned, is that a symptom of a toxic does is vomiting, which can help prevent it turning into a lethal dose. This is somewhat enabled by the tendency to consume it over time (although "binge" drinking does happen, of course). Can the same be said for GHB? Presumably not, given your next comment. > However, being an illegal substance, you don't really know how potent your stuff is. I think that's an issue for any illegal drug, but it's, arguably, even an issue for alcohol. How many people look at a label to determine proof/%ABV? They're not likely offered the chance with a mixed drink at a bar. > Ketamine is rather high (38). Is that medical or recreational? My understanding (possibly incorrect) is that the recreational dose is generally much higher, or at least less spread out over time, which can significantly affect the ratio. Is there any synergy with alcohol here that affects it? Reading more about "safety ratio", it seems that even just the use of the 50th percentile may not be appropriate to have informed decisions on the relative danger of recreational drugs that are likely to be mixed. ED99/LD1 seems extreme, but maybe not ED80/LD20.