You have to be very careful with false positive rates with something like breast screening, as the work up rate has definite negative consequences. Radiologist

You have to be very careful with false positive rates with something like breast screening, as the work up rate has definite negative consequences. Radiologists have too high a false negative rate on such screens, so you're trying to achieve a balance. To be really blunt about it, you are trading off complications/deaths from missed cancers against complications/deaths from biopsies, but these categories occur at very different rates.