I asked something similar in a reddit AMA[1] with Mark Blaskovich, from Open Antimicrobial Drug Discovery. His answer wasn't super satisfying, but for what it's

I asked something similar in a reddit AMA[1] with Mark Blaskovich, from Open Antimicrobial Drug Discovery. His answer wasn't super satisfying, but for what it's worth: > The resistance genes will likely remain, but be 'switched off', so resistance would re-emerge quickly. The cycling approach could theoretically work to some extent, but the logistics on a worldwide scale would be impractical. Mark B [1] https://www.reddit.com/r/science/comments/3k32wi/american_chemical_society_ama_series_im_mark/cuuedmi/ https://www.reddit.com/r/science/comments/3k32wi/american_ch...