If you take anything that blocks certain dopamine receptors (as some bipolar meds do) that might affect it. I've heard claims that SSRI can cause downregulation

If you take anything that blocks certain dopamine receptors (as some bipolar meds do) that might affect it. I've heard claims that SSRI can cause downregulation of the other neurotransmitters over time, but I don't think I've read a study of that.