CAR-T cell therapy is a new way to treat blood cancers. T cells are taken from a patient, genetically modified to target specific cancer cells, then readministe

CAR-T cell therapy is a new way to treat blood cancers. T cells are taken from a patient, genetically modified to target specific cancer cells, then readministered to the patient One issue is that sometimes the T cells don't survive or replicate enough once readminstered to effectively fight cancer In one particular patient whose cancer was completely destroyed, 94% of the engineered CAR-T cells were sequenced and found to derive from one single T cell clone. In this T cell, the genetic engineering process accidentally altered another gene. These mutant T cells demonstrated different epigenetic activity and functional roles as memory T cells