4 ms·
A single T cell's ancestors killed a patients cancer
- aaavl2821 8y agoCAR-T cell therapy is a new way to treat blood cancers. T cells are taken from a patient, genetically modified to target specific cancer cells, then readministered to the patient One issue is that sometimes the T cells don't survive or replicate enough once readminstered to effectively fight cancer In one particular patient whose cancer was completely destroyed, 94% of the engineered CAR-T cells were sequenced and found to derive from one single T cell clone. In this T cell, the genetic engineering process accidentally altered another gene. These mutant T cells demonstrated different epigenetic activity and functional roles as memory T cells
- homophonic 8y agoThis title is not correct. From TFA: Unexpectedly, at the peak of the response, 94% of CAR T cells originated from a single clone in which lentiviral vector-mediated insertion of the CAR transgene disrupted the methylcytosine dioxygenase TET2 gene. A correct title would read: "A single /ancestor/ T cell's *descendents* carried out most of the attack on a patient's cancer"