Classes vs. prototypes is just static vs. dynamic inheritance. You'll generally have the same arguments as those between static and dynamic typing. They're both

Classes vs. prototypes is just static vs. dynamic inheritance. You'll generally have the same arguments as those between static and dynamic typing. They're both "powerful" in their own right: static code tends to be faster to run, dynamic code tends to be faster to write. Depends on which you value more in a given circumstance.