Subsonic/Ampache wins when it comes to client support. mStream's biggest downside is the lack of good mobile clients. mStream has an advantage in the areas of

Subsonic/Ampache wins when it comes to client support. mStream's biggest downside is the lack of good mobile clients. mStream has an advantage in the areas of DB and installation. mStream makes use of LokiJS, an in-memory DB that is VERY fast. mStream also comes packaged as a single click installer for Win/OSX (see the release pages for this). These installers have no dependencies and are configurable via a GUI, making very easy for non-technical people to setup their own home servers. mStream is also taking a turn to support a different market in the future. I'm working on adding eCommerce tools to the server, so bands and musicians can use it as a way to sell music/merch without having a 3rd party take a cut of the revenue. Also mStream will always be FOSS, if that matters to you