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I took Hydrocodone recreationally once, as I had some leftovers from my ribcage injury. Aside from enhanced dreams and occasional hypnogogia, I still didn’t rea

I took Hydrocodone recreationally once, as I had some leftovers from my ribcage injury. Aside from enhanced dreams and occasional hypnogogia, I still didn’t really see the appeal. You can achieve the same euphoria with THC (IIRC, OPRM1 gene expression is altered upon consumption of THC). OPRM1 is an interesting gene, though. Habitual use of morphine (and other substances like alcohol, OPRM1 expression is implicated in risk-taking behavior) would create reinforcement effects and increased gene expression of OPRM1. That would lead you down the dark path of addiction.

girvo 8y ago
Hydrocodone is comparatively weak, and as it’s a codeine derivative it’s at the mercy of your particular genes and how they express CYP2D6 — my girlfriend is a terrible metaboliser of it, and so a lot of narcotics don’t work very well for her. It’s fascinating stuff. Edit: also, you really can’t get the same euphoria from THC. Similar, sure, but not the same — THC doesn’t build life destroying addiction though, so definitely recommend instead!
- ShabbosGoy 8y ago
  > Edit: also, you really can’t get the same euphoria from THC. Similar, sure, but not the same — THC doesn’t build life destroying addiction though, so definitely recommend instead! I can see that. THC feels like a “cleaner” mental euphoria to me, especially without the synergistic effects of cannabinoids like CBD and CBN. I noticed both physical and mental euphoria with Hydrocodone. Not unlike the pleasure of wearing a warm sweater and sitting by the fire on a bitingly cold winter’s day. In my case, I didn’t like the sluggishness (and itchiness!) associated with that feeling, though.
beat 8y ago
Hydrocodone is deliberately weak, to the point where it's hard to get high from it. It's like comparing the pleasant burn of a sip of whiskey to getting hammered drunk. It's not really representative of a true opiate high experience.

girvo 8y ago

Hydrocodone is comparatively weak, and as it’s a codeine derivative it’s at the mercy of your particular genes and how they express CYP2D6 — my girlfriend is a terrible metaboliser of it, and so a lot of narcotics don’t work very well for her. It’s fascinating stuff. Edit: also, you really can’t get the same euphoria from THC. Similar, sure, but not the same — THC doesn’t build life destroying addiction though, so definitely recommend instead!

ShabbosGoy 8y ago
> Edit: also, you really can’t get the same euphoria from THC. Similar, sure, but not the same — THC doesn’t build life destroying addiction though, so definitely recommend instead! I can see that. THC feels like a “cleaner” mental euphoria to me, especially without the synergistic effects of cannabinoids like CBD and CBN. I noticed both physical and mental euphoria with Hydrocodone. Not unlike the pleasure of wearing a warm sweater and sitting by the fire on a bitingly cold winter’s day. In my case, I didn’t like the sluggishness (and itchiness!) associated with that feeling, though.

beat 8y ago

Hydrocodone is deliberately weak, to the point where it's hard to get high from it. It's like comparing the pleasant burn of a sip of whiskey to getting hammered drunk. It's not really representative of a true opiate high experience.