It's somewhat of a downside and an upside with the medication I take -- it's not a "take it when there's a problem" but a "take it all the time" kind of drug.

It's somewhat of a downside and an upside with the medication I take -- it's not a "take it when there's a problem" but a "take it all the time" kind of drug. In this case, because mine were so frequent, I'd be taking them regularly anyway so a daily pill as prevention works really well for me. My body also has a really bad time with anything that messes with serotonin -- I can't take SSRIs (these are sometimes prescribed for Migraine, but usually as a last resort), I can't take triptans (IANAD, but if I understand it correctly, they're mode of operation is to boost serotonin levels[0]). I've had absolutely no issues on Depokote. The one side effect that it has for me was reducing my anxiety. The crazy thing was that I would have never identified as someone with an anxiety problem, but once I the medicine started working, I noticed that my general outlook on life was a lot more 'calm'. [0] Or the specific triptan I was on did that as a side-effect ... I discovered this difficulty of mine as a result of getting serotonin shock/syndrom. That was fun!