As a former South Floridian who used the heck out of my Disney passes for the ~15 months I had them... US-27 is the way to go. Much less stressful and you're ne

As a former South Floridian who used the heck out of my Disney passes for the ~15 months I had them... US-27 is the way to go. Much less stressful and you're never far from civilization from South Bay on up. Can get a bit trafic-y around Sebring but generally it's an easy smooth drive. Or go around the east side of Lake Okeechobee at South Bay, 98/441. Less civilization, more tourist traffic and having to deal with passing zones... but still a nicer ride than the Turnpike. Either way takes a bit longer but the scenery is nicer. For middle Florida values of nice scenery, anyway -- I greatly prefer the mountains.