Probably all the germs you have heard about are different than when they were first characterized, more or less durable than as studies have shown, strictly tra

Probably all the germs you have heard about are different than when they were first characterized, more or less durable than as studies have shown, strictly transmissible through any pathway but practically limited in pathway, and dose-dependent. There's strains of stuff never detected or isolated, there are seven billion people. Try not to think about it!! It is neither strictly possible nor ethical to study transmissible disease in vivo, because tissues cannot be inspected in vivo during infection. In vitro experimentation and blood testing do not have the same preconditions as a person's living tissue. Even high-volume blood tests are fallible, why Theranos got in trouble. Patient self-reporting and some experiments varying in ethical character from "An immunologist developed and self-tested a vaccine first" to "subjects were purposefully exposed by scientists without their knowledge or consent" give epidemiologists and physicians a set of heuristics for preventative care and treatment.