You would have to run non-sandboxed features via a server, which can run on the user machine! Chrome, Firefox, Opera, IE, Edge supports starting the browser in

You would have to run non-sandboxed features via a server, which can run on the user machine! Chrome, Firefox, Opera, IE, Edge supports starting the browser in "chrome"-less or "app" mode, so the program will feel native. You could also run the server part in the cloud! And use "add to desktop" to get the "chrome"-less mode which is currently supported on Chrome and Firefox on Android. Or just run the app in a browser tab :)