Why would you strain your wrist? You don't need to have mouse strictly perpendicular to the display, it can sit at an angle and you only move it relatively to t

Why would you strain your wrist? You don't need to have mouse strictly perpendicular to the display, it can sit at an angle and you only move it relatively to the "resting" position. I use large and ten-key keyboards everywhere and my mouse has at least 20-30 cm of free space to the right side of keyboard - no fatigue issues at all and my wrist on mouse hand is always straight.