> some people generally have low stomach acid Not to the extent that you (and many others) believe. The stomach is always very acidic (pH 1–3), and this acidit

> some people generally have low stomach acid Not to the extent that you (and many others) believe. The stomach is always very acidic (pH 1–3), and this acidity is tightly regulated. Contrary to what you’ve said, the pH is raised (and hence acidity lowered) when consuming food (because HCl is used up in the digestive process). That said, much of the digestion of RNAs happens through enzymes, not acid, so the point is moot. It’s known that the human GI tract is highly efficient in digesting oligonucleotides. Very little (and of that, only small fragments) has a chance of being taken up.