2 ms·
I was surprised to find so many studies regarding the relationship between long-term memory, an enzyme (PARP-1, usually associated with DNA repair and inflammat
by jonmc12 8y ago
I was surprised to find so many studies regarding the relationship between long-term memory, an enzyme (PARP-1, usually associated with DNA repair and inflammation), and RNA. Seems relevant to Glanzman's research, but not cited.
In 2004 the enzyme PARP-1 was linked to long-term memory in Aplysia[1]. In 2009 another study claimed that PARP-1 was also required long-term memory in Mammals[2]:
"Previous results linked the activation of PARP‐1 with long‐term memory formation during learning in the marine mollusk Aplysia (Science 2004, 304:1820–1822).. Mice were tested in two learning paradigms, object recognition and fear conditioning.. These findings implicate PARP‐1 activation in molecular processes underlying long‐term memory formation during learning."
Another study of mice "demonstrated that augmentation of the stability of pro-inflammatory mediator mRNAs presenting a regulatory mechanism of PARP1 in gene expression at the post-transcriptional level".[3]
[1] http://science.sciencemag.org/content/304/5678/1820 http://science.sciencemag.org/content/304/5678/1820
[2] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2009.06296.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159....
[3] https://www.nature.com/articles/ncomms14632 https://www.nature.com/articles/ncomms14632