To me, the beautiful thing about this zappa approach is that I still follow the spec of a UWSGI-compliant app and I get the benefit of quick deployment to lambd

To me, the beautiful thing about this zappa approach is that I still follow the spec of a UWSGI-compliant app and I get the benefit of quick deployment to lambda without any form of vendor lock-in as it is also straightforward to plug the same app into, say nginx, without code change.