2 ms·
Hyperinsulinemia (https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/hyperinsulinemia/faq-20058488 https://www.mayoclinic.org/disease
by calvano915 8y ago
Hyperinsulinemia (https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/hyperinsulinemia/faq-20058488 https://www.mayoclinic.org/diseases-conditions/type-2-diabet...) is mostly prevalent among those with Type II DM (insulin resistance promoting over-production of insulin in a physiologic attempt to compensate). I don't believe all that many "normal/healthy" individuals have this issue. So while gluconeogenesis is a viable pathway for fuel, in most individuals lipid metabolism will not be skipped over for gluconeogenesis because as mentioned previously it is the slowest and least efficient pathway for ATP production. Someone with a persistent high carb and low fat diet may be in a similar state but with high demand for energy - such as the conditions described in the article - the most efficient pathways will be utilized predominantly, unless the individual went to great lengths to prevent it via their diet.